Never mix Prozac with Ecstacy

Researcher of the University of Maryland, Baltimore have recently published a paper in American College of Clinical Pharmacology annual meeting regarding combination of the antidepressant drug Prozac and the club drug Ecstasy increases the risk of acute toxic effects of Ecstasy. And according to them this is one of the leading cause of Ecstasy-related deaths.

Researcher’s said increasing number of Ecstasy abusers are combining the drug with Prozac in an effort to counteract the depression that occurs after the drug’s high wears off. Ecstasy, also known as MDMA, helps the body relax, reduces inhibitions and increases energy and brings feelings of euphoria.

They measured brain and blood levels of MDMA in mice after a 5 mg/kg-dose of MDMA. Levels were also measured after pretreatment with Prozac followed by 10 mg/kg MDMA. And according to data pretreatment with Prozac increased brain and plasma MDMA levels by 40 per cent in the animals. The ‘half-life’ of MDMA, meaning how long the drug is present, increased from 2 hours to 5 hours with Prozac pre-treatment. There was also a 26 per cent reduction in MDMA clearance when the drugs were combined.

So the conclusion is Prozac administered with MDMA decreases the disposition of MDMA and its metabolite, and may increase risk of MDMA acute toxic effects. So never ever mix Prozac with Ecstacy.